Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
نویسندگان
چکیده
منابع مشابه
TCR down-regulation controls T cell homeostasis.
TCR and cytokine receptor signaling play key roles in the complex homeostatic mechanisms that maintain a relative stable number of T cells throughout life. Despite the homeostatic mechanisms, a slow decline in naive T cells is typically observed with age. The CD3gamma di-leucine-based motif controls TCR down-regulation and plays a central role in fine-tuning TCR expression and signaling in T ce...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-019-14112-2